Hemophilia & Other Bleeding Disorders

Welcome to the Blood CME Center’s Hemophilia and Other Bleeding Disorders Education Center. This educational channel has been developed by experts in congenital and acquired factor deficiencies to deliver high–quality, clinically practical education to clinicians dedicated to treating patients with hemophilia and other bleeding and clotting disorders. Exclusive CME programs include interactive learning activities and personalized modular learning forums.
 
 
 
Hemophilia/Bleeding Disorders Journal Club
Scanning the World’s Literature on Bleeding Disorders

Welcome to the Blood CME Center’s Hemophilia/Bleeding Disorders Journal Club! This novel online resource serves as a platform for the dissemination of current literature featuring the latest data relative to the treatment and management of patients with congenital and acquired bleeding disorders, such as hemophilia. Clinicians can stay current with important developments in the field through the original literature and expert commentary found on this site.

Select a Journal Club Topic
Blood Component Therapy in Trauma Guided With the Utilization of the Perfusionist and Thromboelastography
Immune Tolerance Induction in 31 Children With Haemophilia A
The Nature of Factor VIIa Binding and Activity, and the Regulation of Procoagulant Activity
Clinical Effectiveness of Radiosynovectomy in Patients With Hemophilia
The Frequency of Moderate to Severe Allergic Reactions to Factor IX in Haemophilia B Patients
Mortality in Mice With a Very Low Protein C Condition
The Challenges Associated With an Aging Hemophilic Population
Intensive Factor VIII Treatment and Inhibitor Development in Non-Severe Hemophilia A Patients
Bypassing Agents, Immune Tolerance Induction, and Prophylaxis in Inhibitor Patients
Recombinant Factor VIII Concentrates and Inhibitor Development Risk
Treatment of Inhibitor Bleeding – Timing is Everything
Measuring Adherence to Episodic Treatment Regimens in Bleeding Disorders
Measuring Adherence to Prophylactic Regimens in Hemophilia
Inhibitor Development in Black Patients With Hemophilia A
Multidisciplinary Approach to the Challenge of Hemostasis
Advances in Hemophilia
Which Patients Should Be Placed on Prophylactic Therapy?
Age-Related Morbidities
Blood Component Therapy in Trauma Guided With the Utilization of the Perfusionist and Thromboelastography
Peer-reviewed by Mark Walsh, MD, FACEP


Blood Component Therapy in Trauma Guided With the Utilization of the Perfusionist and Thromboelastography
Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, Swearingen A, Navari RM, Ploplis V, Castellino FJ
Immune Tolerance Induction in 31 Children With Haemophilia A
Peer-reviewed by Meera Chitlur, MD


Immune Tolerance Induction in 31 Children With Haemophilia A: Is ITI Less Successful in African Americans?
Callaghan MU, Rajpurkar M, Chitlur M, Warrier I, Lusher J
The Nature of Factor VIIa Binding and Activity, and the Regulation of Procoagulant Activity
Peer-reviewed by Maureane Hoffman, MD, PhD


Platelet Binding and Activity of a Factor VIIa Variant With Enhanced Tissue Factor Independent Activity
Hoffman M, Volovyk Z, Persson E, Gabriel DA, Ezban M, Monroe DM
Clinical Effectiveness of Radiosynovectomy in Patients With Hemophilia
Peer-reviewed by James V. Luck, Jr, MD


Radiosynovectomy in Hemophilia: Quantification of its Effectiveness Through the Assessment of 10 Articular Parameters
De La Corte-Rodriguez H, Rodriguez-Merchan EC, Jimenez-Yuste V
The Frequency of Moderate to Severe Allergic Reactions to Factor IX in Haemophilia B Patients
Peer-reviewed by Michael Recht, MD, PhD


A Retrospective Study to Describe the Incidence of Moderate to Severe Allergic Reactions to Factor IX in Subjects With Haemophilia B
Recht M, Pollmann H, Tagliaferri A, Musso R, Janco R, Neuman WR
Mortality in Mice With a Very Low Protein C Condition
Peer-reviewed by Mark Walsh, MD, FACEP


An Accompanying Genetic Severe Deficiency of Tissue Factor Protects Mice With a Protein C Deficiency From Lethal Endotoxemia
Castellino FJ, Donahue DL, Navari RM, Ploplis VA, Walsh M
The Challenges Associated With an Aging Hemophilic Population
Peer-reviewed by Gerard Dolan, MD, FRCP, FRCPath


The Challenge of an Ageing Haemophilic Population
Dolan G
Intensive Factor VIII Treatment and Inhibitor Development in Non-Severe Hemophilia A Patients
Peer-reviewed by Suchitra S. Acharya, MD


In Non-Severe Hemophilia A the Risk of Inhibitor After Intensive Factor Treatment Is Greater in Older Patients: A Case-Control Study
Kempton CL, Soucie JM, Miller CH, Hooper C, Escobar MA, Cohen AJ, Key NS, Thompson AR, Abshire TC
Bypassing Agents, Immune Tolerance Induction, and Prophylaxis in Inhibitor Patients
Peer-reviewed by Suchitra S. Acharya, MD


Clinical Issues in Inhibitors
Astermark J, Santagostino E, Hoots WK
Recombinant Factor VIII Concentrates and Inhibitor Development Risk
Peer-reviewed by Suchitra S. Acharya, MD


Rate of Inhibitor Development in Previously Untreated Hemophilia A Patients Treated With Plasma-Derived or Recombinant Factor VIII Concentrates: A Systematic Review
Iorio A, Halimeh S, Holzhauer S, Goldenberg N, Marchesini E, Marcucci M, Young G, Bidlingmaier C, Brandao LR, Ettingshausen CE, Gringeri A, Kenet G, Knöfler R, Kreuz W, Kurnik K, Manner D, Santagostino E, Mannucci PM, Nowak-Göttl U
Treatment of Inhibitor Bleeding – Timing is Everything
Peer-reviewed by Christopher E. Walsh, MD


The Value of Early Treatment in Patients With Haemophilia and Inhibitors
Kavakli K, Yesilipek A, Antmen B, Aksu S, Balkan C, Yilmaz D, Kupesiz A, Sasmaz I, Lindgren P, Mesterton J
 
The Need for Speed in the Management of Haemophilia Patients With Inhibitors
Salek SZ, Benson GM, Elezovic I, Krenn V, Ljung RCR, Morfini M, Remor E, Santagostino E, Sørensen B
Measuring Adherence to Episodic Treatment Regimens in Bleeding Disorders
Peer-reviewed by Natalie A. Duncan, MPH


VERITAS-PRN: A New Measure of Adherence to Episodic Treatment in Bleeding Disorders
N. Duncan, W. Kronenberger, C. Roberson, A. Shapiro
Measuring Adherence to Prophylactic Regimens in Hemophilia
Peer-reviewed by Natalie A. Duncan, MPH


VERITAS-Pro: A New Measure of Adherence to Prophylaxis Regimens in Hemophilia
N. Duncan, W. Kronenberger, C. Roberson, A. Shapiro
Inhibitor Development in Black Patients With Hemophilia A
Peer-reviewed by Tom E. Howard, PhD


The Role of Immune-Response Gene Variants in Inhibitor Development in Black Patients With Hemophilia A
Tom E. Howard, Shelley A. Cole, Carol K. Kasper, Afshin Ameri, Kavita Natarajan, Raymond G. Watts, Valrie A. Manard, Shelley M. Nakaya, Christine L. Kempton, Martina Kennedy, Benjamin Kim, Rathi V. Iyer, Laura Almasy
Multidisciplinary Approach to the Challenge of Hemostasis
Peer-reviewed by Jerrold H. Levy, MD, FAHA


Multidisciplinary Approach to the Challenge of Hemostasis
Jerrold H. Levy, Richard P. Dutton, J. Claude Hemphill III, Aryeh Shander, David Cooper, Michael J. Paidas, Craig M. Kessler, John B. Holcomb, Jeffrey H. Lawson; Hemostasis Summit Participants
Advances in Hemophilia
Peer-reviewed by Nidra I. Rodriguez, MD


Advances in Hemophilia: Experimental Aspects and Therapy
Nidra I. Rodriguez, W. Keith Hoots
Which Patients Should Be Placed on Prophylactic Therapy?
Peer-reviewed by Prasad Mathew, MD, FAAP


Devising a Best Practice Approach to Prophylaxis in Boys With Severe Haemophilia: Evaluation of Current Treatment Strategies
M. Carcao, H. Chambost, R. Ljung
 
Prophylaxis in Haemophilia With Inhibitors: Update From International Experience
M. Carcao, T. Lambert
 
Venous Access in Haemophilic Children: Choice and Management
E. Santagostino, M. E. Mancuso

Age-Related Morbidities
Peer-reviewed by Prasad Mathew, MD, FAAP


How I Treat Age-Related Morbidities in Elderly Persons With Hemophilia
Pier M. Mannucci, Roger E. G. Schutgens, Elena Santagostino, Evelien P. Mauser-Bunschoten
 
Emerging Clinical Concerns in the Ageing Haemophilia Patient
B. A. Konkle, C. Kessler, L. Aledort, J. Andersen, P. Fogarty, P. Kouides, D. Quon, M. Ragni, A. Zakarija, B. E. Wenstein

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